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Edvotek Sickle Cell Gene Detection (DNA-based)
Item #:
2134037
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In this Sickle Cell Anemia experiment, your students will investigate the restriction enzyme that discriminates between HbA (normal) and HbS (disease) genes and perform a simulated test on a patient.
About This Item
Description
Sickle Cell Anemia is a common genetic disease that causes long rods in red blood cells, giving them a "sickled" appearance. These cells get stuck in small capillaries of the blood stream leading to oxygen deprivation that causes pain and organ damage. Sickle Cell Anemia is caused by a single point mutation in the hemoglobin gene that results in a faulty protein.Features
- Discover how a single nucleotide mutation can profoundly affect a person’s health
- Explore Mendelian genetics and the molecule methods used to identify sickle cell disease
- Perform agarose gel electrophoresis to separate differently-sized DNA molecules
- Load, run, analyze, and size control samples and samples from a family of three to identify mutations in their hemoglobin genes
- For 8 Gels
Includes:
- Instructions
- Ready-to-Load QuickStrip DNA Samples
- UltraSpec-Agarose
- Electrophoresis Buffer (50X)
- Practice Gel Loading Solution
- FlashBlue DNA Stain
Specifications
Allergens:
Contains No Allergens
Maximum Age:
18+
Maximum Grade Level:
Grade 12 +
No Choking Hazard